Chemical changes during contraction of rabbit taenia coli.
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چکیده
منابع مشابه
Mechanism of relaxant action of papaverine. Effect on caffeine-induced contraction of guinea pig taenia coli.
The mode of action of papaverine on smooth muscle relaxation was examined through analyzing its effects on caffeine-induced contraction of guinea pig taenia coli, which might be due to calcium ion mobilized from intracellular store sites. Caffeine contraction induced in normal solution at 32 degrees C was decreased in the presence of papaverine but increased after the removal of papaverine, and...
متن کاملCaffeine and Excitation-Contraction Coupling in the Guinea Pig Taenia Coli
The effects of caffeine (0.2-10 mM) on the electrical and mechanical activities of guinea pig taenia coli were investigated with the double sucrose-gap method. Caffeine evoked a small tension with a latency of 20-30 sec, then phasic contraction developed and finally relaxation. The initial tension development also appeared in the Na-free solution without any marked changes in the membrane poten...
متن کاملKinase-related protein/telokin inhibits Ca2+-independent contraction in Triton-skinned guinea pig taenia coli.
KRP (kinase-related protein), also known as telokin, has been proposed to inhibit smooth muscle contractility by inhibiting the phosphorylation of the rMLC (regulatory myosin light chain) by the Ca2+-activated MLCK (myosin light chain kinase). Using the phosphatase inhibitor microcystin, we show in the present study that KRP also inhibits Ca2+-independent rMLC phosphorylation and smooth muscle ...
متن کاملNO donor sodium nitroprusside inhibits excitation-contraction coupling in guinea pig taenia coli.
In guinea pig taenia coli, the nitric oxide (NO) donor sodium nitroprusside (SNP, 1 microM) reduced the carbachol-stimulated increases in muscle force in parallel with a decrease in intracellular Ca(2+) concentration ([Ca(2+)](i)). A decrease in the myosin light chain phosphorylation was also observed that was closely correlated with the decrease in [Ca(2+)](i). With the patch-clamp technique, ...
متن کاملRole of Metabolism in K-induced Tension Changes in Guinea Pig Taenia Coli.
PFAFFMAN, M., N. URAKAWA, AND W. C. HOLLAND. Role of metabolism in K-induced tension changes in guinea pig taenia coli. Am. J. Physiol. 208(6) : I 203-1205. I g65.-Further insight into the underlying mechanism(s) of the K-induced phasic and tonic contractions of the taenia coli of the guinea pig was obtained by examining the effects of various metabolic intermediates, inhibitors of metabolism a...
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ژورنال
عنوان ژورنال: Japanese Journal of Pharmacology
سال: 1980
ISSN: 0021-5198
DOI: 10.1016/s0021-5198(19)53475-8